Louay Hussein is a Syrian writer and activist. He is the co-founder and president of Building the Syrian State.

Hussein was among the first to be detained by Syrian authorities for expressing support for the protesters in Deraa at the start of the uprising in March 2011. He openly defied the authorities by organizing a public gathering of over 190 opposition figures in Damascus on June 27, 2011, and subsequently co-founded the Building the Syrian State movement with other intellectuals and activists on September 13.

Louay Hussein was born to an Alawi family in Damascus in 1960. He studied philosophy at the University of Damascus and was arrested in 1984 for joining the illegal opposition Communist Labor Party. He was jailed for seven years without trial until his release in 1991.In 1996, he founded a publishing house called Dar Petra, but its activities were restricted by the security services. His memoir of his years in prison, Loss, was published in 2005 in Lebanon. Since then, has also published most of the newspaper articles he has written in Lebanon as well. Hussein is subject to a travel ban and remains in Syria.